tag:blogger.com,1999:blog-5491220859163652191.post6386573595109534293..comments2024-02-25T13:20:09.766-08:00Comments on Stranger than you can imagine: Physiology behind the Magic Light Helmet for Alzheimer'sdaedalus2uhttp://www.blogger.com/profile/10416564922288784455noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-5491220859163652191.post-61271552057208527832012-10-08T07:26:54.134-07:002012-10-08T07:26:54.134-07:00"My mother and both her parents died with adv..."My mother and both her parents died with advanced Alzheimer's, so I am not being flip, I know what it can do. But that the brain can function so well and for so long with such a serious decline in metabolism is quite remarkable to me. One of the things that has helped me in my research is that I inherited my mother's low nitric oxide physiology, so I experienced quite dramatic changes when I corrected it (I appreciate that my experiences are anecdotes)."<br /><br />What is low nitric oxide physiology? How was it diagnosed and how did you correct it?jaymondhttps://www.blogger.com/profile/01850163040601404419noreply@blogger.comtag:blogger.com,1999:blog-5491220859163652191.post-513406562440578752012-04-11T09:22:28.993-07:002012-04-11T09:22:28.993-07:00Thanks so much for your article, quite helpful mat...Thanks so much for your article, quite helpful material.idssinfohttp://www.idssinfo.comnoreply@blogger.comtag:blogger.com,1999:blog-5491220859163652191.post-46324422520613667712012-03-05T04:24:10.218-08:002012-03-05T04:24:10.218-08:00I enjoyed your article. Please pass by and visit m...I enjoyed your article. Please pass by and visit my project. David http//www.indiegogo.com/The-Alzheimers-Blitzkrieg?a=441422Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5491220859163652191.post-43982477783340699072009-02-14T06:06:00.000-08:002009-02-14T06:06:00.000-08:00I looked at your site, and all of the anti-inflamm...I looked at your site, and all of the anti-inflammatory effects of LLLT are consistent with the mechanisms that I discuss. <BR/><BR/>One of the papers you cite, (Chow RT, David MA, Armati PJ. 2007) looks interesting. I have only seen the abstract, but from that, the effects discussed are completely consistent with the mechanisms that I discuss. My discussion in my second post on the magic light helmet is better than this one. <BR/><BR/>Axons forming varicosities is a clear sign of ATP depletion. They see other very clear signs of ATP depletion. If that ATP depletion proceeds too far, it will cause cell death. It will cause axon necrosis. Inhibiting ATP production is (to me) a poor and dangerous way of producing anesthesia. I see it as similar to using asphyxiation as anesthesia, smother someone until they pass out and they won't feel any pain. No thank you, I prefer drugs that act only on pain receptors and keep 99.999% of the other functions of the cells intact, rather than mess with ATP which affects everything. ATP depletion can cause euphoria; that is the euphoria of near death metabolic stress, the runner's high, the euphoria of autoerotic asphyxiation. Euphoria can be a sign you are at deaths door. A magic light helmet that makes you feel good? Amphetamine makes you feel good too. <BR/><BR/>The light doses of LLLT are enormously higher than occur in nature. There can be no evolved function for these non-physiological light levels. It is extremely implausible that there are physiologically relevant "photoreceptors" on mitochondria. What possible physiological function could they have? There are many organisms with mitochondria that live their entire lives in complete darkness. In any case, non-physiological levels of anything are most likely to have non-physiological effects. Non-physiological effects are most likely to be adverse. Without an understanding of what those effects are, which requires an understanding of the mechanism(s) involved, when seemingly beneficial effects will become adverse is unknown. <BR/><BR/>There may be stimulatory effects of LLLT at some doses and inhibitory effects at other doses and toxic effects at other doses. The doses required to produce those different effects are likely different in different cells. Those differences have not been measured and are unknown for the various cells in the brain. <BR/><BR/>Treating the peripheral nervous system with light is likely completely different than treating the CNS with light. The cell bodies contain the DNA and cellular machinery to make proteins and to generate new mitochondria. The cell bodies are very often remote from the nerves being treated in the peripheral nervous system, in the CNS they are not. A damaged axon can regenerate if the cell body remains intact. If the cell body is damaged, the entire nerve and all its axonal extensions is gone. <BR/><BR/>I haven't looked at the clinical trials for all the various treatments that LLLT is being used for. Most of them are for infrequent brief treatments on small peripheral sites for limited periods of time. This is quite different than what the magic light helmet is being used for which is chronic long term treatment of large volumes of CNS. Have there been animal trials with these levels of brain irradiation? If so, I have not seen them, and the results were not cited by those doing experiments on humans. <BR/><BR/>I don't think there is any reason to expect that clinical trials would have shown the adverse effects that I expect to see, unless people were looking for them, and those running these trials don't seem to be looking for adverse effects long term.daedalus2uhttps://www.blogger.com/profile/10416564922288784455noreply@blogger.comtag:blogger.com,1999:blog-5491220859163652191.post-16927174028066761942009-02-14T01:38:00.000-08:002009-02-14T01:38:00.000-08:00Daedalus Your knowledge of the inner workings of ...Daedalus <BR/><BR/>Your knowledge of the inner workings of the mitochondria and the electron transport chain is way over my head so I can't comment on your reasoning, HOWEVER perhaps we could take a step backwards and see the bigger picture: <BR/><BR/>You do not mention / refer to LLLT (Low Level Laser Therapy) or Photobiomodulation (or the colloquial term "cold laser therapy") which is the most common nomenclature for the NIR / magic helmet therapy you blogged about. <BR/><BR/>LLLT has been clinically used therapy for 40 years, one of the primary mechanisms is the effect on mitochondrial production of ATP. <BR/><BR/>The clinically studied effects are mostly on reduction of inflammation, pain and improved tissue regeneration. LLLT has been a MeSH term used on Pubmed since 2002 and it is already showing 1585 papers. Over 100 RCT’s have been published and I expect that if the adverse effects you fear were going to occur we would have seen other evidence of it by now. <BR/><BR/>What do you think. <BR/><BR/>See my LLLT blog:<BR/><BR/>BLOG http://blog.thorlaser.com/<BR/>TWITTER http://twitter.com/thorlaser<BR/>WEB http://www.thorlaser.com/<BR/><BR/>P.S. I used to play game on my Mac called Daedalus, is that where you got your handle from ?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5491220859163652191.post-7196213986432666312008-08-10T15:16:00.000-07:002008-08-10T15:16:00.000-07:00Meryl, I sent you an email with some stuff on CFS....Meryl, I sent you an email with some stuff on CFS. Did you get it? <BR/><BR/>My most recent post talks about mitochondrial shut-down. I think all the various mechanisms lead to the final common pathway of too much superoxide.daedalus2uhttps://www.blogger.com/profile/10416564922288784455noreply@blogger.comtag:blogger.com,1999:blog-5491220859163652191.post-72489335278976055702008-08-10T11:56:00.000-07:002008-08-10T11:56:00.000-07:00Thanks for commenting on my anthrax vaccine blog.I...Thanks for commenting on my anthrax vaccine blog.<BR/><BR/>I have been thinking about mitochondria and CFS and other conditions including GWS for 15 years, since learning that Cuba's neuropathy epidemic was due to poisoning of oxidative phosphorylation, and had much (but not all) in common with CFS. It had everything in common with Leber's hereditary optic neuropathy.<BR/><BR/>Meryl Nass, MD<BR/>mnass@gwi.netMeryl Nass, M.D.https://www.blogger.com/profile/07001997291638442225noreply@blogger.comtag:blogger.com,1999:blog-5491220859163652191.post-78544405561187825232008-02-13T09:09:00.000-08:002008-02-13T09:09:00.000-08:00steelgraham@hotmail.comsteelgraham@hotmail.comAnonymoushttps://www.blogger.com/profile/06161711368434758108noreply@blogger.com