Showing posts with label theory of mind. Show all posts
Showing posts with label theory of mind. Show all posts

Sunday, March 14, 2010

The physiology behind xenophobia

The roots of racism, bigotry, sexism, intolerance; why people with autism are bullied so much and why some parents of autistic children have said their child would be better off dead if the autism could not be “cured”. I think this is the motivation behind the curebie mind set that some NT parents have.

This relates in part to the concept of the African philosophical term Ubuntu: being human through other humans and how lack of Ubuntu causes xenophobia. This derives from trying to understand the cognitive and communication differences in autism spectrum disorders. The concept of becoming a person through other people exactly fits with this, but in a much more literal sense than (I think) is understood in Ubuntu as a philosophical concept.

I am thinking of this not in any moral or ethical sense, rather in a purely physiological and psychological sense, how do we, as human animals, recognize and learn to recognize other entities as “human”, and how does the “human essence” that is recognized as “human” occur and develop. Considering what “essence” of someone is perceived to be “human”, and how, also leads to what happens when that “essence” is not perceived is what I think leads to the perception that someone is “non-human”, i.e. what triggers xenophobia. I am using “human” as being synonymous with “non-other” or “someone who is not so different from me that it is not OK to treat them badly”.

In other words, how do we recognize someone, something outside ourselves as something that should be treated as a fellow human being? As a brother, sister, neighbor, peer, or as an alien? As an enemy, someone who cannot be trusted and who does not deserve the normal rules of hospitality that apply to neighbors, kin and fellow human beings?

As I have been writing this it has gotten more involved and matrix-like, rather than a linear argument that is easily understood. The basic point I am trying to get across is that understanding any communication requires a Theory of Mind that matches the person you are trying to communicate with. When the two theories of mind don't match, the increased error rate triggers xenophobia via the uncanny valley effect. NT people of different races and cultures trigger xenophobia because the content of their NT ToMs doesn't match. ASDs trigger xenophobia in NTs because the fundamental structure of the ASD ToM doesn't match the NT ToM. Most of the examples I use are from politics because it is very easy to see that the xenophobia exhibited by political partisans does not have a basis in fact. The feelings of hatred come first, the arguments to support the feelings come later.

Ideas based on feelings or on facts and logic.

This feeling, that someone who is not like me belongs to a class which may be treated differently than me and my group, is a feeling, and so may be difficult or impossible to analyze rationally because at its core it is not rational. Feelings derive from physiological states, not from facts and logic. It is unreasonable to expect feelings to be rational. The feeling that one's own feelings are rational and are to believed is the essence of truthy. Stephen Colbert coined the term and discusses it saying:

Truthiness is tearing apart our country, and I don't mean the argument over who came up with the word…
It used to be, everyone was entitled to their own opinion, but not their own facts. But that's not the case anymore. Facts matter not at all. Perception is everything. It's certainty. People love the President because he's certain of his choices as a leader, even if the facts that back him up don't seem to exist. It's the fact that he's certain that is very appealing to a certain section of the country. I really feel a dichotomy in the American populace. What is important? What you want to be true, or what is true?…
Truthiness is 'What I say is right, and [nothing] anyone else says could possibly be true.' It's not only that I feel it to be true, but that I feel it to be true. There's not only an emotional quality, but there's a selfish quality.”
It is the selfishness of truthy that is its most important characteristic. It is the implicit assumption that one individual's feelings have a privileged access to truth over all other individuals. This is the essence of xenophobia, an individual's personal subjective assessment that another does not have what ever human essence it requires for that person to be a peer or equal, or even someone to not be abused or killed.
How I arrive at this is somewhat complicated. Just bear with me and try to understand the whole thing before you pick it apart. There are a lot of concepts I am trying to pull together, and putting them in a logical form isn't that easy and I have been pressed for time. I feel I need to bring up a lot of background and definitions in order for the overall concept to be understood. Not everything is in a good sequential order for easy understanding. My intent in this is not to be pejorative, but to be descriptive, to describe traits such as xenophobia as they are, so that individual bearing such traits can choose to change them (or not) as they wish. I appreciate that there is considerable stigma attached to bigotry, racism and xenophobia, and being accused of such is considered a great insult. My intent is to explain the physiology behind the feelings of xenophobia so those feelings can be understood and I hope modified or at least not acted upon. Feelings of xenophobia are morally neutral. Acting on feelings of xenophobia is not morally neutral, those actions are immoral and damaging to all involved, both the victim, the perpetrator, the enabler and the uninvolved observer.
I have an earlier version on my blog which more closely focuses on the different thinking styles on the autism spectrum. In this write-up I am trying to explain xenophobia. Why it happens, how to recognize it, how to stop it from causing problems and how to change people so they don't experience xenophobia. Getting people to not experience xenophobia is more difficult and takes their active participation in adults, not so much in children. Peer pressure can be used to compel this, but it takes active pressure and many xenophobes are in denial and resistant to change because xenophobia is such an important part of their self conceptualization. To change and become non-xenophobic means to become in part that which they now despise. This is quite important. To be non-xenophobic, one must be able to understand the other, and the only way one can understand the other is to be able to think like the other, and if one can think like the other, then one has become other-like in the most fundamental way. If one begins to understand the other before one stops hating the other, then as one's understanding increases so does one's self-hatred.
In the sense that I am using it, a Theory of Mind (ToM) produces output i.e. feelings that are direct input to another part of the ToM. The output of the ToM is “transparent”, that is there is no access to the lower hierarchical input, or the process by which the output is derived. An insulting facial expression or gesture triggers the feeling of being insulted without the conscious observation and registration that the gesture comprised a number of fingers arrayed in a particular order, or lips turned at a particular angle, and that in this particular culture that particular hand sign has a particular meaning. The gestures and body language that lead to the feelings that one is being lied to, being insulted, being put down, being loved, can't be expressed in words because the “language” that the communication is occurring in is not verbal.
I think that xenophobia is purely an outcome of a ToM and that a theory of reality (ToR) does not (and can not) lead to xenophobia. I think this is mostly because the ToM deals mostly with feelings, and those feelings are “primitives”, that the conscious brain does not have access to and good control over, and is difficult to change, and difficult to reject when they are wrong or when they don't follow from premises. In contrast a ToR is easier to change and is under much better conscious control. One adopts a ToR because it actually corresponds with reality, not because one wants to, or because one feels it is correct. In general if you have a belief and you can't derive it from facts and logic, then it is a ToM feeling, and not a ToR fact. One can have mistaken ToR “facts”, but if you refuse to change them when they are shown to be mistakes, then they are actually ToM feelings. Being able to appreciate this dichotomy is virtually impossible for someone without a good ToR.
People with a strong ToM want to be perceived to be correct because it gives them power in a human power hierarchy. They will attempt to impose their ToM on others to exert control over them. To some extent a ToM can be projected. Charismatic leaders have a strong ToM that they can use, and project and get other people to adopt. The actual truth value of the ToM is irrelevant to those using it, it is completely arbitrary. Groupthink, is an example of what can happen in an organization when ToMs are allowed to run things. The Wiki discussion points out very nicely the difficulty in problem solving in a hierarchy. When success depends in part on pleasing those higher up in the hierarchy, Groupthink is a natural consequence, which can only be avoided with substantial effort, as discussed. Groupthink lead to the serious problems of the Bay of Pigs, JFK recognized that and tried to avoid it during the Cuban Missile Crisis (fortunately he did, or we might not be here today). Drinking the Kool-Aid is another expression that means essentially the same thing. It is essentially accepting someone else's Truthy as your own.
The term Reality Based Community was originally meant as a pejorative term, applied to those who were not in political power and so had to react to the “reality” that the Neocons with political power were “creating”. Trying to create “reality” via force of will is a ToM construct.
People with a strong ToR want to be actually correct and will change their ToR when they find it to be in error. People with a strong ToM want to be perceived to be correct and want you to change your ToM to match theirs, and (in the limit) will kill you if you don't. Avoiding being killed is the ultimate reason why there is the ToM switch in Stockholm Syndrome. Threats of violence to induce adoption of a policy are virtually always ToM derived.
Truthy is a pure ToM activity, as is the postmodernism idea that everything is relative. The modernism idea of rejecting prior ideas can also be a ToM activity if another ToM is substituted for the one that is rejected. The closest things that correspond to ToR activity are Skepticism (particularly as exemplified by the James Randi Educational Foundation) and also science as exemplified by Richard Feynman. In particular see Feynman's discussion of Cargo Cult Science. I have a quote of his that exemplifies the degree of intellectual honesty that is necessary for a good ToR on my blog: “The first principle is that you must not fool yourself – and you are the easiest person to fool.” Very smart people can fool themselves. How one uses one's ability to reason is what determines the outcome. Skeptics use their intelligence to try and make their ToR correspond with actual reality by changing their ToR; Denialists use their intelligence to trick themselves into thinking reality corresponds to their ToM.
To be a good skeptic, or to have a good ToR, you can only argue from facts and then only using valid logic. If you make up your own “facts”, or use invalid arguments, you are not being a skeptic.
Denialism is a pure ToM activity. I think that some of the ideas I am expressing here are semi-consistent with the Jungian idea of the Collective Unconscious being equivalent to a shared ToM. However a ToM in the sense that I am using it is only shared within a group of humans and I don't posit any non-physical or metaphysical action at a distance to explain it or how it arises, just simple physiology. It is not “universal” in any sense. What can be universal is the overlap, the lowest common denominator of a mob for example. One does need a ToM that overlaps with social animals to understand and predict their behavior (for example dogs), and even to some extent non-social animals such as predators. Non-social animals do not really have a ToM that can be shared, so trying to understand and control them is not possible, hence the expression “herding cats”. Non-social animals do sometimes need to communicate, for example to mate, and also for predators to predict what their prey is doing, but the ToM needed for that level of communication is quite simple. It is not just that non-social animals can't be understood, the animal does not have the capacity to understand what social interaction is because it doesn't have the brain structures to instantiate that understanding.
It has been said that "Organizing autistics is like herding cats." I think this expression relates the similarities between autistics and cats as not having a robust ToM that is shared between the would-be cat (or autist) herder and the objects of their herding attempts.

Thinking requires neuroanatomy to instantiate idea.


The only way anyone can think about something is if that person has the neurological hardware to instantiate the mental concept. If the mental concept cannot be “mapped” onto the neuroanatomy of the brain, the idea cannot be held in that brain, the idea cannot be thought about. I am using “neuroanatomy” in the most general sense, a configuration of brain matter/stuff. All changes in the mind result from and are caused by changes in the physical structure of the brain (which I am calling neuroanatomy even though it may be sub-cellular in nature).

Understanding that someone without the neural hardware to instantiate the idea is unable to think about it is difficult. Most human thinking is transparent, that is it takes very little effort. It is only coming up with completely new ideas that is difficult, but like all things it always looks easy in hindsight. Bora has a good example of that kind of thinking in regarding science journalism:

You understand that it is impossible for a single person to gain a full understanding of every area of science.

- Can you play violin?
- Sure, of course
- Have you ever played?
- No. But it looks easy, I'm sure I can do it.

This is how non-scientists often think about science.”

This is how people who lack the neural hardware to understand an idea often think about the idea. They are unable to actually think about it, so they are unable to evaluate if the concept is easy or difficult. With a ToR, you know if you have or don't have a chain of logic leading from facts to what you believe is true. With a ToM, there is only the feeling, the process by which the feeling was arrived at is transparent, it is completely unknown. Sometimes the path can be figured out, that is one of the things that psychotherapy and psychoanalysis is used for. In day-to-day use, where feelings come from is mostly unknown.

Facts are independent of the neural network that instantiates them. Feelings are subjective products of the neural network that instantiates them. Feelings change due to the physiological state of the brain, facts do not. When you are tired, angry, hungry, sick, or running from a bear, feelings change and the pathways by which feelings are used to derive other feelings change. Facts do not change and the logic that connects facts does not change.

Learning is the process by which neuroanatomy remodels itself so the new neuroanatomy can instantiate the learned idea.

Being ignorant of a mental concept is equivalent to having a neuroanatomy that does not support instantiating the mental concept that one is ignorant about. The only one can become non-ignorant is to learn the concept which means modifying your neuroanatomy so the idea can be instantiated.

Learning can be looked at as modification of the brain's neural network so the new neuroanatomy can support what ever new idea it is that is being learned. This change in neuroanatomy takes a time that is dependent on how similar the new idea is to ideas that can already be instantiated.

In computers, there is a distinction made between hardware and software. There is no such distinction in natural neural networks, there is only “hardware”. I don't want to get into a mind-body argument. This is written from a completely materialistic perspective, that there are no ghosts or immaterial minds, or spirits that have influences other than through chemistry, physics and quantum mechanics. The brain is only hardware, but that hardware can change with a time constant of less than a second. That is what memory does, it records (via some unknown process) ideas in short term memory and later consolidates it into long term memory. Both of those are hardware in the sense that I am using, the sense that there are actual physical objects, cells, molecules, networks that have changed state and the “data” is recorded in that changed state, and the physics and chemistry of those physical objects determines the properties of the “memory”. It is fundamentally not like computer memory, where the type of memory does not affect the data and where “data” in the sense of software can direct the hardware to perform calculations. In brains there is only hardware, but that hardware is very complicated and can change second-to-second. A ToR in essence emulates a computer where “facts” and “logic” can be stored so they are not changed by a change in the emotional state of the organism.

Learning physics or mathematics is difficult because the normally developing neural patterning doesn't spontaneously support that type of thinking the way it supports language. Language acquisition occurs spontaneously. Essentially all infants learn to speak essentially any language that they are exposed to as infants, without an accent and with no special effort. It is not that language acquisition is easy or simple, rather that evolution has configured humans to have very powerful language acquisition systems; that either a language is spontaneously acquired, or a new language is generated de novo.

Learning is a process of neurodevelopment which must follow a path. The neuroanatomy is reconfigured a little bit at a time through neuronal remodeling to transition from the state before the mental concept can be instantiated to the neuroanatomy after the mental concept can be instantiated. Memory is a simple example, but one that requires very complex neuronal remodeling, the details of which is still not understood, yet it happens completely transparently. This is why most learning has to start with the basics, then once the basics are learned more complex ideas can be learned, and so on. The early learning configures the neuroanatomy into a state where it can be reconfigured again for later learning, and again, and again throughout the entire lifespan.

Theory of Mind: absolutely necessary for any communication

I discuss much of this in a hypothesis of autism in an earlier post.

My understanding of xenophobia and othering starts with an understanding of how people communicate, that is through a shared “theory of mind”. A “theory of mind” in this context is the cognitive hardware that converts a data stream of language into a mental concept and back. When two people communicate, the first one translates a mental concept into a data-stream of language, the data is transferred, the second person receives the data-stream through their senses, and then up converts the data-stream into a mental concept. Fundamentally, the only things that can be “communicated” are mental concepts, and those mental concepts can only be communicated if the two individuals share a common “theory of mind”, the same (or close enough) mapping of a data-stream of language onto mental concepts. What is critically important is that both individuals have neural structures that are both able to instantiate the same mental concept that they are both thinking about. If they are unable to instantiate the same mental concept, they are unable to communicate about that mental concept. All communication necessarily is a two-person activity. A failure to communicate is also a two-person activity, a failure to communicate cannot be localized to one individual.

Communication and language acquisition: the compulsion of peer pressure

Because infants are unable to speak but yet can learn to speak essentially any language as a first language with no accent, the ability to communicate in a specific language is not innate but is a product of neurodevelopment (which is innate). Usually infants will adopt the language of the majority population, usually the language of their parents.

Social animals communicate with each other. In humans the brain structures to support language and language development must be coded for genetically. Language itself must be learned or is synthesized de novo during certain periods of brain development. This point is quite important. When humans are growing up in a culture, they adopt the language of the culture, provided that the language is "well formed". If the language the adults are using is not "well formed", the children synthesize a new language that is "well formed". That is, when the children of immigrant parents grow up, they do not adopt the pidgin language their parents are speaking, they either adopt the "well formed" dominant language, or synthesize a new "well formed" Creole. The various sign languages did not become "well formed" until children grew up with signing as their first language, which they modified into a "well formed" language. This is well documented in the development of Nicaraguan sign language.

The acquisition of language in this way tells us several things; that the ability to acquire language is innate, and that there is a more "primitive" cognitive structure underlying language (by that I mean that the structure of "cognition" has a component that is hierarchically simpler than the linguistic components humans communicate with), and that neurodevelopment of language acquisition is to some extent directed by that underlying cognitive structure in ways that are transparent, i.e. not observed or noticed. Without a simpler and more primitive cognitive structure, the Creole could not be unconsciously analyzed as it is being formed to ensure the resulting Creole has a "well formed" grammar and that the specific well-formed language corresponds to what the other children are using. However, the ability to form a Creole is lost at a certain age. The immigrant parents of the Creole synthesizing children continue to speak their pidgin language. This implies that the cognitive structure that analyzes language as it is being learned and forces the develop0ing neuroanatomy to instantiate a language that is "well formed", i.e. to conform to standard default human linguistic patterns is lost (to some extent) with age. It also implies a compulsion to learn the "standard" language and a compulsion to force others to comply with the "standard".

Some individuals may not lose the ability to acquire new languages with as high fidelity as “first languages”. That ability is extremely rare and insufficiently characterized for me to discuss it further. It is not the case that the only type of “languages” that humans can understand are languages that fit the “well-formed grammar” of first languages. Pidgin languages do not fit a well-formed grammar and yet can be understood.

The development of a de novo language, such as a Creole, is a collective outcome produced by a population. It is not produced by a single individual. Another way of describing it is that the population developing the language acquires a shared neural mapping of the medium of the language (sounds, gestures, etc) to neural structures producing the mental states that are the ultimate outcome of communication (that is the ideas being communicated). In this context, there is no arbitrarily correct mapping. The mapping is correct so long as it is the mapping shared by the group. In the sense of this quote: “In any great organization it is far, far safer to be wrong with the majority than to be right alone.” (John Kenneth Galbraith); what ever the majority adopts as the linguistic mapping is the correct mapping. This is a very important point. What ever the majority adopts as correct is correct; everything else is wrong. The ability to incorporate something arbitrary into a ToM is important. It allows and is necessary to support Doublethink the holding of two contradictory ideas simultaneously while believing both of them.

For a single majority linguistic mapping to arise spontaneously there must be very powerful mechanism(s) to eliminate deviation from the mapping acquired by the majority. The majority acquire a shared Theory of Mind with respect to linguistic mapping. In other words, the differences between the shared Theory of Mind and that of any individuals in the population are reduced. The deviation is not reduced by changes to the shared theory of mind; the deviation is reduced by individuals adopting the shared ToM as their own.

This is an important point. There is no "shared" ToM. There are only individual ToMs which correspond to the shared ToM more or less. The shared TOM can only be shared to the extent that all individuals have the same components and the same structural relationships between those components. The shared ToM reflects the "lowest common denominator"; the ToM that overlaps with everyone else's ToM is all that can be shared. I think this relates to the importance of "peer pressure" in the age group capable of forming a Creole language. If peer pressure were not so compelling, a single coherent language would be difficult or even impossible to achieve.

As mentioned earlier, the parents of the generation that develops the Creole continue to speak their pidgin language. They do not participate in the Creole formation because their ToM is insufficiently plastic. Their ToM has become “fixed”.

The rigidity of an inflexible ToM maintains stability of communication over your lifetime, and of information transmitted culturally to the next generation. If your ToM doesn't support an idea, you cannot transmit it, cannot receive it, cannot understand it, or cannot even think it. When times are easy, transmitting the cultural information that led to those easy times is important. It is important to do so with high fidelity because it worked. When times are hard, the culturally transmitted information isn't working, and so needs to be abandoned or modified. The fidelity of transmission must be reduced so what ever is wrong and/or isn't working can be eliminated. I think the “hard times” skews neuronal remodeling in utero to a less social phenotype, to more toward the ASD end of the ASD spectrum. Exposure to stress in utero does increase the incidence of autism.

The “theory of mind” encompasses all communication modalities, spoken language, sign language, text, music, lip reading, gestures, and very importantly body language where emotional states are communicated. Much of the communication of emotional states is likely unconscious and we don't have conscious access to everything that is being communicated, especially when what is communicated are emotional states. What is communicated results in feelings, feelings of unease, feelings of trust, feelings of respect, feelings of every type. The details of those feelings are very important. The details of feelings produced by translation of the data stream is also a part of the ToM that is learned during early to mid childhood. This is a major mechanism by which xenophobia can be learned, peer pressure compels adoption of what the peers are doing. One has to go along to get along, even to the extent of ostracizing those that are different.

That is why being ostracized hurts. It has to be aversive or it would not be effective at enforcing a single shared ToM. Avoiding the feelings of hurt are what compel people to “go along”. It is what compels people to change their ToM, to acquire the local accent, local customs, local gestures, local ways of feeling, local ways of ostracizing those who are not “local”. I think that this is the basis for mob rule, and why as Friedrich Nietzsche said “Madness is rare in individuals - but in groups, parties, nations, and ages it is the rule.” The ToM of the mob is the lowest common denominator, the intersection of the ToM of all the individuals in the mob. The larger the mob, the smaller the intersection, and the smaller and less complex ideas can be collectively understood. I think this is why mobs tend to descend into hatred, violence and fight or flight stress responses. Those are the most primitive and universal feelings. Mobs also tend to exclude those who would provide a moderating influence.

Nietzsche also said: “The surest way to corrupt a youth is to instruct him to hold in higher esteem those who think alike than those who think differently.” I think by “corrupt” Nietzsche means “stunt the ability to think and understand”.

NT infants and children have an enormous compulsion to acquire a NT-type ToM. That compulsion is what drives the NT brain to organize itself in the NT neuroanatomy. NTs end up with communication being their “savant” ability. In ASDs, the “compulsion hardware” compels acquisition of other skills, skills that are more randomly distributed and which end up being the savant skill of that particular individual. I think this is why there is so much more diversity in ways of thinking among people with autism. ASD children have less compulsion to be the way everyone else is.

I think (but this is somewhat more speculative) that the “compulsion” module is more flexible in ASDs, and can even be “programmed” to a greater extent than in NTs. I suspect that OCD is what happens when the compulsion module gets focused on a particular and semi-dysfunctional activity. Of course, what is considered to be dysfunctional is in the mind of the beholder. To become expert in any activity, athletics, music, science, acting, writing, fighting, weaving, making stone tools, train spotting, requires extreme levels of practice. Having a compulsion to repeatedly do a task is a way to spontaneously develop expertise in that task. It takes about 10,000 hours to be come expert in a field. If you haven't spent that kind of time, you are not an expert.

ToM and pattern recognition

How communication works, is that a data stream is transferred, decoded by the ToM and matched to mental concepts via pattern recognition, either familiar mental concepts or mental concepts generated de novo. Pattern recognition is a well understood ability. All systems instantiating pattern recognition are subject to different forms of error. There is the type 1 error, the false positive, the error in wrongly identifying a false instance as positive. There is also the type 2 error, the false negative, the error in missing the correct identification of a correct instance. In a general sense any pattern recognition system can be made more sensitive, that is with a reduced type 2 error, but then there is an increased type 1 error and there are more false positives.

If there is good consilience between the “theory of mind” of the two individuals, they can communicate complex ideas in ways that are robust and nuanced. If there is not good consilience, then the communication is poor. So far I have only talked about communication and in the sense I am meaning it this communication is neutral, it has no moral or ethical component and the communication conveys no value judgment.

What triggers xenophobia

I think (and this becomes speculative now) that when two people meet, they do in effect a “Turing Test”, where they try to communicate and see if the other individual is “human enough” to trust and communicate with. I think that this hinges on whether one individual's “theory of mind” can match or emulate the “theory of mind” of the other individual and so can understand how they are thinking and can predict their responses. You are only “human enough”, if your “theory of mind” matches the “theory of mind” of the other individual. If there is insufficient consilience, then the communication error rate goes up, you fail the “Turing Test”, and xenophobia is triggered (my hypothesis) via the “uncanny valley” effect.

I see the triggering of the uncanny valley effect as being due purely to physiology and not within conscious control and so does not have a moral or ethical component. How one then responds is under conscious control (more or less) and so does have a moral and ethical component. I think this provides an explanation for a lot of human group interactions, including religions, xenophobia, bigotry and racism in all of its forms.

Michelle Dawson has a very good post about Turing and brings a modern perspective to his classic and prescient paper. Turing was gay, and experienced considerable abuse as a consequence. Abuse that ultimately led to his suicide. I think it is ironic (and very tragic) that the man who first conceived of the Turing Test in effect “failed” it as far as other humans were concerned.

I think it is the lack of consilience in the two ToMs that leads to the failing of the Turing Test and the triggering of xenophobia. It kind of has to be that way, because without consilience of the ToMs, the two individuals cannot exchange any information. They may exchange data, sounds, gestures, facial expressions, but without a ToM to translate that data into mental concepts, no information is being conveyed. What is being noticed is that there is a lack of communication going on. The error rate goes up, both type 1 and type 2 errors; getting false mental concepts that are not conveyed and missing the mental concepts that are being attempted. When those false mental concepts trigger emotions, distrust, unease, hatred, fear, distress, then fear of the other, xenophobia is happening.

I suspect that the underlying cognitive structures that enforces the development of a single Creole in children develops into the cognitive structure that does the Turing Test in adults. The compulsion of trying to communicate and behave like everyone else develops into rejecting and feeling antipathy toward everyone who doesn't behave and communicate as you do. (hypothesis)

This is where the selfishness of truthy comes in. If you privilege your own feelings above all other things, facts, logic and the feelings of others, then your mental state is unreachable. You are incapable of having a discussion because you are unable to even consider ideas different than your own.

Under this hypothesis, xenophobia comes from an inability to recognize someone as human (a type 2 error, a false negative), and derives from an inability to emulate their thinking processes and so understand their actions, motivations, and mental states. The xenophobe then substitutes (i.e. projects) what ever is convenient or what ever they are thinking (a type 1 error, a false positive) onto the person that is not understood.

Examples of xenophobia showing non-matching ToM and resulting inability to understand (mostly drawn from politics)

A classic example is when George Bush tried to explain the actions of those who flew planes into the WTC on 9/11 as “because they hate our freedoms”, which makes no sense at all. What train of logic leads from “hating freedoms” to hating people not living under a dictatorial authority to killing essentially random people in a murder-suicide? There is no train of logic. The logical explanation is that 9/11 was perpetrated to provoke a certain response, as in providing Bush with an excuse to go to war with Iraq (who played no role in 9/11) and that the expected war with Iraq would further the cause of Al Qaeda (which it abundantly did). Bin Laden played Bush perfectly, and he fell right into his trap.

In Sun Tzu's The Art of War, (III Attack by stratagem), he says:

18. Hence the saying: If you know the enemy

and know yourself, you need not fear the result of a

hundred battles. If you know yourself but not the enemy,

for every victory gained you will also suffer a defeat.

If you know neither the enemy nor yourself, you will

succumb in every battle.

Knowing the enemy” is being able to understand their thinking processes sufficiently well so as to emulate them and to be able think the way that they do. The xenophobia that George Bush exhibits is extremely dangerous in a leader, and disastrous (as observed) in a military leader.

Similarly the post 9/11 Iraq war was started with what was called “shock and awe”; with the “idea” being that individuals would be so “shocked” and “awed” that they would simply surrender. Really? What level of “shock and awe” would it take to cause Americans to simply surrender? Not surprisingly “shock and awe” didn't work. Many aspects of the initial stages of the Iraq war didn't work. They didn't work because they were produced by people completely ignorant of war and how people act when in a war, and refused to listen to people who did understand. The decision to go to war was made on the basis of Groupthink, not reasoning.

The recent Tea Party political activity in US politics can also be seen to derive from xenophobia and bigotry and not from disagreements about policy. People can disagree with President Obama and hate him for his policies, but when someone hates President Obama for policies that he does not have, the source of the hate cannot be due to his policies (because the hated policies are not his). For example when Sarah Palin hates Obama because of his “death panels” and her assertion that Obama wants to kill her son, we know that President Obama has not proposed “death panels”, and so the source of Sarah Palin's hate cannot be “death panels”, the hate must have another source. Sarah Palin's accusation of President Obama that he is proposing “death panels” is what is called a blood libel. A false accusation of heinous murder. The hating came before the blood libel because the events claimed in the blood libel never happened. The blood libel is a lie thought up to rationalize the hatred that Sarah Palin feels. The hating came first, then the blood libel, and then the blood libel can't be analyzed rationally because it “feels right” because of the hatred.

Similarly, Antisemitism and Christian hating of Jews came first, and the Antisemitic blood libel against the Jews (the lie that Jews use the blood of Christians in Passover rituals) came later. When I was about 10 years old, a Catholic boy of similar age told me that Jews used the blood of Christians in Passover rituals. I knew at the time that didn't make any sense and couldn't be true because Passover pre-dated Christianity so there could have been no Christians for Jews to use the blood of at earlier Passover ceremonies. I knew it made no sense and couldn't be true, but the boy who was telling me this believed it was true. He believed it was true because he had been told it was true. No one who told the story had ever seen it happen because it never did happen.

Similarly, left handedness has been a reason for people to be discriminated against.

In the context of bombing Iran to stop their nuclear program I have asked people who have spoken positively about bombing Iran and so stopping the Iranian nuclear program to tell me the number that would make the US surrender. Usually they respond that there is no number that would make the US surrender, not hundreds or even thousands. When asked what is different about the Iranians that one or two would cause their surrender, they are unable to reply other than by saying “but they would have to”. But in the exact same circumstances they acknowledge that US citizens would never surrender. It is the labeling of Iranians as “the other” that allows wishful thinking to project the wish of how they would act for an expectation and generate the false belief that the expectation is reasonable.

Experts in nuclear weapons find no credible reasons to expect Iran to abandon nuclear weapons following a bombing of their nuclear facilities and many reasons to expect an attack to accelerate their acquisition of them. So why is an action that cannot be expected to achieve its stated goals “on the table”? Why did presidential candidate John McCain considered bombing Iran when no credible experts on Iran, or on military activities consider that it would be successful? It is clear that John McCain is expressing that belief for a different reason, either consciously or unconsciously. That tactic by a would-be leader only works when the followers are profoundly ignorant of the group being talked about, and are willing to remain ignorant. It is a Groupthink type of reasoning.


I think this same inability to understand the other as human is involved in the gay marriage debate. Homophobic individuals are unable to conceive of gay people as fully human, and so are unable to conceive of them as having the capacity for human emotions such as love. Homophobic individuals can't imagine that a lesbian mother actually loves her child, or that her child could possibly love his/her gay mother, so the homophobe imagines that the child would be better off in foster care with an individual who might have the capacity to love and be loved.

When homophobic individuals talk about their fears of “gay culture”, what they are talking about is their fear of people being non-homophobic. One doesn't need to be gay to be non-homophobic, but many homophobic individuals are unable to appreciate that. A large part of the homophobic mind set occurs because they are attracted to same-gender individuals. They are afraid of gay culture being acceptable because it is something they can imagine themselves wanting to do. As a result, they assume everyone is like them, and the only thing keeping society from becoming the gay culture they are afraid of is the gay bashing they are doing. They are trying to enforce the Groupthink they exhibit in their narrow homophobic group.

There is an effort to repeal the “don't ask, don't tell” policy of the US military toward homosexuals. I think that eliminating xenophobia of all types in the US military is absolutely essential for them to be able to do what ever missions the civilian leaders call on them to do. As I am trying to demonstrate, xenophobia derives from an inability to understand the other. If the other cannot be understood, then the actions of the other cannot be predicted, and the other cannot be reasoned with. Diplomacy requires understanding by both sides. War, being diplomacy by other means requires it too.

Individuals of a particular group can experience xenophobia toward themselves. This is complicated and is usually tied up with abuse and the physiology behind Stockholm Syndrome. Being alive but at the bottom of a social hierarchy is better than being dead. A good description of the phenomena is tied up in a term from the history of slavery in the US, the term House Negro. A better discussion of the term is found on the blog Field Negro. Essentially the House Negro was a slave in the master's house, and had a better life with easier working conditions than the Field Negro who was a slave in the fields and was worked brutally hard. The easier life the House Negro had was built on the back of the Field Negro.

I think this is the same thinking process that lead to the taking away of children from indigenous peoples, from non-white parents by the white majority. This happened in the US, in Canada, and in Australia. I suspect that adults have somewhat higher innate connections to children, even children of different ethnicity, than they do to adults. Before those children have their own fully developed ToM, they likely are not rejected by adults. Once the ToM does develop (or does not develop so as to be consilient with the adult ToM), then xenophobia could be triggered. Removing children from their culture of origin is a way to destroy that culture. If a new generation does not grow up with that culture and language as their first language and culture, then they are lost.

In folklore, there is the mythology of changelings, the idea that a human child was stolen and a non-human child of identical appearance substituted in its place. I suspect that this is how the curbies of an earlier time rationalized the feelings they had for their autistic children. Some of them even use the metaphor of their child being stolen by autism, as if autism is an object or entity that can be anthropomorphized and then hated or blamed.

I think there are some similarities in Deaf Culture. I think the major motivation for Deaf Culture and the rejection of cochlear implants in deaf children is so that the deaf children will grow up with signing as their first language and will acquire the ToM of the Deaf Culture they grow up in. To not have a ToM that is shared by your parents is to be rejected by those parents as a changeling, and also to reject those parents. I think that deaf parents of a child who cannot sign would have feelings toward that child similar to feelings of NT parents with an autistic child. The relevant physiology is the lack of consilience between the ToMs.

I suspect that being bi-lingual with signing as one of the languages is somewhat more difficult than being multi-lingual with spoken languages because of the difficulty of making cross-connects between visual and aural senses and between hand signals and vocal muscle systems. Those difficulties are probably less than the difficulties of learning a language in the first place and likely less than the language difficulties that autistic individuals have. The communication deficits that ASDs have encompasses both language and body language, so it is likely more profound than in Deaf Culture.

As I was putting the finishing touches on this, a particularly illustrative example appeared in the news. Harry Reid, the Democratic Majority leader in the Senate, just had his wife injured in an automobile accident, where she broke her back and neck. A conservative blogger is calling on Harry Reid to “pull the plug” on her, to euthanize her. Why? Because the Right Wing Blogger can't imagine that Harry Reid has the capacity to love his wife. Love is something that only “humans” can exhibit. Since Harry Reid is a Democrat, and a liberal, he can't possibly be capable of feelings like love. It is pure projection, pure xenophobia, pure bullying. Designed (probably unconsciously) to hurt Harry Reid, those associated with Harry Reid, and to send a message to non-liberals that if you leave the Right Wing Conservative group, this will be your fate too.

There was a moment in 1954, in the Army-McCarthy hearings when Joseph McCarthy attacked a young lawyer, and Joseph Walsch said his very famous line:

Senator, may we not drop this? We know he belonged to the Lawyers Guild. Let us not assassinate this lad further, Senator. You've done enough. Have you no sense of decency, sir? At long last, have you left no sense of decency?”

In truth Joseph McCarthy didn't have a sense of decency. A sense of decency is reserved only for those one feels are fellow human beings. If someone is not felt to be a human being (because they lack a ToM that can be related to as such), then considerations normally given to fellow humans, such as decency, do not apply.

Ubuntu: the basis of humanism

I think the physiology behind the philosophy of Ubuntu is the actual root of humanism. That is the root of the physiology that makes it difficult for some people to kill other humans. In the past many soldiers were simply unable to kill other humans. Modern basic training has evolved to overcome that, the unfortunate side effect (which I think is an immutable aspect of being able to kill other humans easily) is PTSD and overt xenophobia (which has to be invoked to kill humans easily).

What counts as “human”, is the ToM that one developed as a child and young adult. That ToM is very much the human “essence” that is detected and measured by others with their own ToM. It is hard to kill others in your peer group. You recognize them with your shared ToM. To induce others to kill, you need to get their ToM to not align with the group that you want them to kill. You have to induce xenophobia via Groupthink type activities to reinforce the desired ToM that will induce xenophobia and prevent the rational thinking that a ToR does.

Being human (developing a human-recognizable ToM) occurs through interactions with other humans. You take in a bit of their ToM, and adopt it as your own. This is what Nietzsche was talking about when he said “He who fights with monsters should look to it that he himself does not become a monster. And when you gaze long into an abyss the abyss also gazes into you.” Your neuroanatomy will remodel itself to be able to do pattern recognition on what ever it is you are exposed to and then to react appropriately to it. To be able to see what is in the abyss, you need to have pattern recognition neuroanatomy that can recognize what is in the abyss, in effect you have to know what is in the abyss before you can see it.

This is why people who want to remain bigots can't have positive interactions with those they are bigoted against. To see the objects of their xenophobia as human and having human characteristics is to cause distress if they are not treated humanely. I think this is why there was such opposition to desegregation and why the GOP cannot accept diversity of opinion and have a Big Tent.

Social Hierarchies: Ubuntu and the Abrahamic Religions

As I have been thinking and writing this, I have been wanting to contrast Ubuntu with the Abrahamic religions. Not because Ubuntu is a religious principle, but because the religious principles of the Abrahamic religions have been claimed to underlie and be necessary for any sense of ethics or morality. This is not the case. The Abrahamic traditions specify a particular type of social structure, that of the top-down Kyriarchy (the Kyriarchy is analogous to the Patriarchy, but with any authority at the top). In the case of the Abrahamic religions, God is at the top, with His Prophets and priests next but above the common people who are followers, who are above non-followers.


The essence of any hierarchy is differential rights and responsibilities. Those at the top have more and those at the bottom have less. This is why power corrupts. The ToM of those at the top becomes modified so it feels as though they are better than those at the bottom, and so should have more and so they take more. More power, more money, more salary, more mates, more of everything.

In essence in Ubuntu it is 'people first'; in Abrahamic religions it is 'God first'. The “Golden rule” of 'doing unto others as you would have them do unto you', only comes after and is secondary to doing what God commands. It is like the rule in Animal Farm, all animals are equal, but some are more equal than others. All of God's children are equal, but those who follow His teachings and do whatever His representatives say to do (the self-proclaimed and self-appointed religious leaders) are more equal than those who do not. Putting God first generates a hierarchy, with those who put God first ahead of those who do not. It is a way of “othering”, a way of classifying people into people who are like us, and people who are “the other” (and so do not deserve normal human considerations) and can be enslaved or put to death at will, just as Moses said to do to non-virgin women and male children (Numbers 31:17).


The God first meme set the stage for the Divine Right of Kings, where because the first born son of the king was to be the next king, the characteristics of that king were put in place by God.

Abrahamic conflict resolution

The Abrahamic “eye for an eye” is similar. Strict punishment doesn't really deter much crime, what it does is classify individuals into criminals and non-criminals, setting up a social hierarchy with criminals at the bottom. Criminals (because they are not like us) can be subjected to maltreatment because they have been dehumanized. They are also dehumanized because they have been subjected to maltreatment. The Abrahamic eye for an eye is completely different than the Ubuntu conceptualization of justice. Justice in the Ubuntu sense is about the society getting along after the crime has happened, not about some “punishment” achieving a “balance”. It is not about a concept like “sin” being balanced by a concept of “punishment”. Justice in a Kyriarchy is about satisfying the “leader”, who will deliver “justice” after his “judgment”. It is about “justice” by fiat by the individual at the top of the hierarchy. The "Justice" is about giving you a new place in the social hierarchy. This is why "leaders" are so difficult to bring to justice. Moving them to the bottom of the hierarchy puts their followers still farther below them.

The incarceration of individuals can make crime worse because the criminals are all put together in the prison community and so the ToM of individual prisoners becomes closer to the average ToM of the prison community. Non-violent drug offenders become violent offenders. Deterrence comes not from fear of punishment (which is always contingent on being caught), but from the aversive effects of violating shared cultural norms, the same aversive effects that enforce those cultural norms in the wider community, and the same aversive effects that enforce the adoption of a shared ToM during language acquisition. When a non-violent drug offender adopts the shared ToM of the prison community (where violence is accepted), the drug offender now becomes more capable of violence.

Restitution in the Ubuntu sense is by doing something positive, by giving back to the community, by the perpetrator (and his/her family) by exhibiting Ubuntu, by doing positive things and acting in positive ways, not by having something negative happen to the perpetrator. How these two concepts work in practice is illustrated by what happen in South Africa when the Apartheid government fell (or rather what did not happen). There was no blood-bath. There was no general retribution on whites in revenge for the generations of maltreatment of blacks. In Europe following WWI, the victors extracted ruinous reparations from Germany, which set the stage for WWII.

Connection to autism, maltreatment of people on the spectrum

Autism spectrum disorders are characterized by deficiencies in abilities to communicate across all communication modalities, including body language, emotional content, nuance and the like with neurologically typical individuals, NTs In ASDs, this is caused by the lack of a ToM that matches the ToM of the NT individual. Unfortunately this activates feelings of xenophobia in NTs.

When one has feelings of xenophobia, feelings of fear, revulsion, antipathy directed toward another individual, one has the choice of how to respond. Unfortunately for NTs, the compulsion of peer pressure that causes the development of the NT ToM also compels acting on those feelings.

Problems with the standard treatment of Theory of Mind

The standard formulation of Theory of Mind, postulates that there is a “standard” way of thinking, and that people with autism are unable to mentalize in this “standard” way, and so they have a deficit in mentalizing due to their defective theory of mind. This is not correct. There is not a single or “standard” Theory of Mind, each individual has a Theory of Mind that is unique. There is no arbitrarily correct mapping of language into mental concepts. There can be no arbitrarily correct ToM. This may be very difficult for NTs to accept. Their ToM is very complex, very structured, full of nuance and with a great deal of data-compression and auto-correction that fills in the gaps in the puny data stream of language to convey mental states that are much more complex than the data stream has the data content to transmit. Two NTs can communicate very complex ideas with very little data because they have enormous amounts of data compression. The compressing and decompressing of that data is done by their ToM, and is completely transparent to them while they communicate. Much of this compression is tied up in shared cultural experiences.

Idioms convey information due to their cultural context. Phrases like the Wikipedia example “kick the bucket” have a cultural meaning that goes beyond the literal linguistic meaning. Idioms are often very difficult for people on the spectrum to appreciate. “Kick the bucket” is an idiom, but can also refer to an example of something one might do to a bucket. People on the spectrum are notorious for taking idioms literally.

How to deal with xenophobia?

This is a difficult problem with two different aspects and two possible solutions. There are the feelings that lead to xenophobia, and then there are the actions that are a result of those xenophobic feelings.

Producing individuals that do not have xenophobic feelings is most easily done in children, by exposure to individuals who are different and the prevention of the ostracizing of children who are different by adults. Mainstreaming children into regular classrooms is (I think) extremely important in accomplishing this for the next generation (of all children). It has to be done carefully, and in particular parents and teachers cannot tolerate or foster abusive behavior toward children who are different than others in the group.

A major problem is that people who have xenophobic feelings don't want to lose those feelings. They want to remain xenophobic because being a part of a community that has a common enemy does provide a sense of community and to lose the xenophobia is to lose being a part of that community. This is because excluding others is an important part of the social dynamic that produces group cohesion. We see this very clearly in homophobic communities, where even the idea of criminalizing discrimination on the basis of sexual orientation is unacceptable. There was a recent case in Virginia, where Virginia public universities had policies in place to forbid discrimination based on sexual orientation, and the Virginia Attorney General wrote them saying that such an anti-discrimination policy was forbidden.

Being in a non-xenophobic community is likely to reduce the xenophobia of the xenophobes by compelling a shift in their ToM to a less xenophobic state. It does require the non-xenophobes making known to the xenophobes that xenophobia is unacceptable. The xenophobes must be made aware that xenophobia is unacceptable but without being excluded from the non-xenophobic community.

The feelings of xenophobia engendered by a ToM are exacerbated under conditions of stress. The “fight or flight” response makes a ToR more difficult to maintain its independence of emotional state. The ToM is the more “primitive” cognitive structure, that is the default that people default back to under stress. The reason that people bully is to put their victims under stress and try and induce Stockholm Syndrome.

Tuesday, October 21, 2008

Theory of Mind vs. Theory of Reality: The tradeoff along the Autism Spectrum

In any great organization it is far, far safer to be wrong with the majority than to be right alone. -- John Kenneth Galbraith

If the only tool you have is a hammer, you tend to see every problem as a nail.
-- Abraham Maslow

In the land of the blind, the one-eyed man is king.

How autism provides resistance to the delusional thinking of groupthink (aka drinking the Kool-Aid).

When your primary competition is with other people, life is a zero sum game. When your primary competition is with reality, there are no limits.

The cause(s) of Autism Spectrum Disorders (ASDs) remain unknown. The complex genetic disorder hypothesis posits ASDs are an emergent disorder of multiple genes, perhaps dozens or more. How a common disorder of so many genes could evolve has not been suggested. One hypothesis is that genes associated with ASDs did confer some advantage resulting in their selection in the past, but are now detrimental. I suggest ASDs are not disorders at all, but normal (even human defining) developmental responses, particularly to stress in utero and early childhood. This fundamental human neurodevelopmental paradigm programs the brain and behaviors mediated by that brain so as to optimize survival and reproduction depending on maternal and infant stress; invoking abilities to understand, interact with and manipulate other humans when times are good, and abilities to understand, interact with and manipulate the environment via tool production when times are hard. It is hypothesized that this trade-off between Theory of Mind (ToM) and Theory of Reality (ToR) is the quintessential trade-off along the Autism Spectrum. Implications for interaction difficulties between individuals with ASDs and Neurologically Typical individuals (NTs) are discussed. Prevention and treatment are also discussed.

Background ASDs

The Autism Spectrum Disorders (ASDs) are defined and diagnosed by difficulties in communication, social interaction and by repetitive behaviors. In ASDs, there is a high (but not absolute) concordance between monozygous twins, [1] moderate concordance between dizygous twins, [2], [3] and lesser concordance between siblings. With no generally accepted environmental cause, ASDs are thought to be primarily genetic in origin with associations of perhaps 135 genes.[4] No doubt the complex effects on brain structure and behavior observed in ASDs are not mediated via a single pathway, but calls to abandon a search for a single explanation are premature. [5]

A number of single mutations have been associated with multiple cases of autism-like symptoms. I call these "autism-like" because it is not clear if the cause and sequelae of these autism-like syndromes are identical to or even similar to the common cases of autism and ASDs (which remain unknown). A good example is Rett Syndrome which is known to be caused by a loss in the MeCP2 gene which is on the X chromosome. Females have 2 copies of the X chromosome, one of which is silenced. Active MeCP2 in some cells rescues the organisms from the fatal loss of MeCP2 which afflicts males (who have only one X chromosome). RS females develop seemingly normally until 6-18 months when they develop the characteristic RS phenotype which includes autism-like symptoms, but is also characterized by non-autistic symptoms of small head size, breathing abnormalities, vascular abnormalities, scoliosis, growth retardation and others. Because the effects of MeCP2 deletion are mediated through aberrant transcription of methylated DNA, then aberrant transcription of methylated DNA is sufficient to lead to autism-like symptoms. Perhaps the symptoms of common ASDs are also caused by DNA methylation, or perhaps via a shared final common pathway triggered by aberrant DNA methylation.

Nitric oxide is a pleiotropic signaling molecule used in thousands of metabolic pathways where it regulates, ATP supply, O2 consumption, steroid physiology, transcription, axon targeting, the cell cycle, epigenetic programming and many other aspects of physiology, development and neurodevelopment. Many of the pathways observed to be abnormal in ASDs are mediated through NO signaling.

I suggest that the final common pathway mediating autism and autism-like symptoms is low NO in utero, during neurodevelopment and as an adult. Low NO is the archetypal stress response. Virtually any type of stress ultimately results in low NO which physiology uses to trigger compensatory responses. For example, oxidative stress occurs when superoxide levels are increased. Superoxide consumes NO at near diffusion limited kinetics so a high superoxide state is necessarily a low NO state. NO inhibits cytochrome c oxidase. To release that inhibition and increase O2 consumption to maximize aerobic ATP production, the NO level must be lowered. Psychosocial stress increases oxidative stress through catecholamine oxidation, ATP stress increases oxidative stress through increased mitochondrial potential necessary to increase ATP flux, xenobiotic stress increases superoxide through the cytochrome P450 pathway, immune system stress increases superoxide through the respiratory burst. Just about any type of metabolic stress would decrease NO levels and according to the present hypothesis would tend to produce a more autistic-like phenotype. This may be the mechanism for the association of copy number variations with autism. This may also be the mechanism behind the ASD-like symptoms produced by MeCP2 deletion. Females with MeCP2 deletion are mosaic. Some of their cells do have appropriate methylation readout and some do not. Presumably this differential regulation of DNA expression causes metabolic inefficiencies and metabolic "stress" due to cells being out of "sync". In a mosaic organ with non-synchronous regulation, some cells would be working harder than others, perhaps even working at cross purposes. The final common pathway of essentially every kind of metabolic stress is decreased NO.

Virtually all ASD physical symptoms are consistent with pathways regulated by NO being skewed in a low basal NO direction. I suggest that the ASD phenotype is a stress compensatory pathway mediated by low NO.

NO/ROS Balance Programs adult physiology in utero

The physiology of virtually all adult organs is known to be programmed in utero in response to a number of fetal stressors including nutrition[6] stress and hormonal factors. [7] NO/ROS balance in utero does lead to epigenetic programming of adult blood pressure in rats. [8] Stress is a low NO state. [9] The most characteristic physical feature of ASD children is a larger brain[10], with smaller and more numerous minicolumns. [11] Low NO is suggested to cause the characteristic minicolumn structure associated with autism[12] and the timing of stressors may be crucial to the development of the autism phenotype. [13] In guinea pigs, brief prenatal stress increases brain/body mass ratio, and changes adult behavior. [14] Prenatal stress increases learning ability in rats. [15] Prenatal stress does program hypothalamo-pituitary-adrenal function. [16] Low NO does cause neuronal hyperplasia. [17] The patterning of many neural structures is determined in part by gradients in NO mediating proliferation, differentiation, or apoptosis. [18] There are increased asymmetries in the brains of ASD individuals[19], suggesting differential regulation of neuronal growth when the sizes of those structures are formed in utero. Stress in utero causes adaptive changes in the adult physiology of multiple organs; it would be beyond surprising if it did not exert adaptive influences on the most important organ, the brain.

I suggest that low NO in utero, brought about by maternal stress leads to the ASD phenotype in affected individuals, and the genotype that leads to the ASD phenotype was adaptive under conditions where humans evolved, in the “wild”, but is perhaps now less adaptive due to environmental change(s). What possible advantages could the ASD phenotype hold?

The Brain is fundamentally the most Human organ

Humans evolved large and complex brains only because such brains conferred survival and reproductive benefits. Human evolution was shaped mostly by events 100k or more years ago. Humans are social animals, as are all primates. Humans are unique in their use of language with syntax and grammar to convey complex ideas. Humans are the only extant hominin that manufactures and uses tools. The first instances of manufactured stone tools date to about 2.5 to 2.7 MYA (million years ago), and was near universal by 2 MYA[20]. Manufactured tools of perishable materials perhaps were earlier. Modern humans are good at tool manufacture and tool use. Tool use has profoundly shaped human evolution and those parts of the human genome that affect brain structures important for tool creation and use. Similarly, communication and language has profoundly shaped human evolution and those parts of the genome that affect brain structures important for language acquisition and use. The major structures of the brain are formed in utero and early childhood, and are then largely fixed throughout adult life. It is only in utero and early childhood that neurons can be epigenetically programmed to form the major structures in the brain with the characteristic neuroanatomy observed in ASDs such as increased asymmetries, larger numbers of neurons[21] and larger brains.

Brain size at birth limited by female pelvis: Brain optimization requires tradeoffs

The size of the newborn brain is limited by the size of the mother's pelvis through which it can be successfully born. In the absence of medical C-section, cephalopelvic disproportion results in significant infant and maternal mortality. What ever advantages a large brain at birth provides it comes to naught if the infant or mother dies. The structure and size of the brain at birth must be an evolved trade-off between the multiple tasks that brain will be called upon to perform at birth and over the life of the individual and the substantial risk during a natural birth. The only time the most fundamental aspects of brain structure can be modified is while those structures are being formed. Much of the formation of those brain structures occurs in utero, much of it in the first trimester following closure of the neural tube (which is when teratogens such as thalidomide can cause autism). Epigenetic programming of cells occurs when those cells are dividing and undergoing differentiation. Much of the differentiation in early human development occurs in the first trimester. Patterns of methylation modify DNA expression and modify the phenotype of that differentiated cell for the lifetime of that cell. Many neurons do not divide over the lifetime of the individual. NO does modify methylation through the folate pathway and so modifies DNA methylation in ways that are quite complex (for at least this one gene system). Presumably multiple genes are epigenetically modified in complex ways by this same mechanism.

Oxidative stress and low NO cause changes in DNA methylation. Presumably this is part of the normal mechanism by which stress (which results in oxidative stress and low NO) causes global epigenetic reprogramming of diverse genes in diverse tissue compartments under diverse circumstances. Psychological stress causes long lasting changes in neurological functioning as for example PTSD. The details of how psychological stresses of what types cause the characteristic neurological changes that manifest as PTSD are mostly unknown. We know it happens, so there must be physiology that supports those characteristic changes.

DNA methylation mediated through NO does influence expression of genes that are involved in some autism-like syndromes, such as Fragile-X mental retardation gene (FMR1). Aberrant readout of DNA methylation is implicated in the autism-like symptoms of Rett Syndrome (RS). Many of the symptoms of RS are characterized by physiology being skewed in the direction of low basal NO.

Fundamental brain optimization tradeoff: Theory of Mind (ToM) for Theory of Reality (ToR)

Humans are unique among animals for their abilities at communication; language making and language using and tools; tool making and tool using. These abilities are highly dependent on a large brain with substantial plasticity for self modification via learning throughout life. The relative importance of these two extremely important human behavioral characteristics is dependant upon the environment the infant is born into. The major neuroanatomy of the brain originates from structures arising during early neuron proliferation and differentiation during and after neurulation in the first trimester. These structures are then elaborated on later in utero. It would be beyond surprising if the relative aptitude of the brain for communication and/or tool making/using (including manual dexterity for manipulating objects) were not to some extent programmed in utero.

That trade-off would show up as a trade-off between abilities to understand and manipulate other humans (Theory of Mind), and abilities to understand and manipulate reality (Theory of Reality). These are the differences that are seen in people along the autism spectrum. I will discuss how a less developed ToM interferes with ASDs communicating with neurologically typical individuals (NTs) and their very well developed ToM. For the most part ASDs don't pick up the nuances of communication, particularly how it relates to motivations, beliefs and other mental states. The NT ToM forces NTs to think in anthropomorphic terms, even when it is inappropriate because they lack a robust ToR.

I spend a lot of time trying to explain this in several different ways using several different analogies. What I am trying to describe is exceedingly complex, as complex as an entire human brain. Something that complex cannot be described simply except in simplistic terms. It would be like trying to describe a library in a single paragraph.

Good times --> Need Good ToM

One hypothesis of this paper is that when times are good, and a woman's first trimester of pregnancy is characterized by low stress, then the "optimum" infant brain will be one optimized for better communication. If times are good, there will be plenty of other humans around, and the infant's primary competition for food and mates will be with other humans. Because times are good, the cultural information the adults have is working well to produce those good times. Copying that good cultural information with high fidelity is important. Good communication, a good ToM with the ability to understand and manipulate other humans is the best strategy when times are good.

Hard times --> Need Good ToR

When times are hard, a woman's first trimester will be characterized by high stress. The optimum infant brain will be skewed away from communication because during evolutionary time, hard times meant fewer humans in the territory. With fewer other humans around the need for communication is reduced. The cultural practices of the adults are not working well to produce good times. If the cultural practices are not working well, they need to be modified until they are working well. When times are hard, there won't be many other humans around because they will die in infancy. Competition will be against reality for food, shelter, and to stay alive. The adults don't know how to make good times, so that is something the infant will have to figure out for him/herself.

Theory of mind, theory of reality and theory of cognition

I will make a distinction between being able to think about something (cognition) and being able to think about that thinking process (meta-cognition) and coin a term Theory of Cognition (ToC), to denote the ability to think about and emulate different types of cognition. The term is an attempt to be analogous to ToM and ToR, which are meta-abilities to think about and compare multiple models of other minds (necessary for communication by emulating other mental states), and multiple models of potential realities. I am making this distinction because the different types of computation that humans do are not necessarily mapable onto each other.

Analogy:
Word processing ToM Theory of Mind Emulating other minds
Spread sheet software ToR Theory of Reality Emulating Reality
Operating system ToC Theory of Cognition Choosing Emulations


Trying to understand human communication with a ToR might be like trying to write a document not with word processing software but with a spread sheet. A document could be written in a spread sheet. It would be slow, cumbersome and the document wouldn't have the right formatting and wouldn't be as polished as something done in a word processor. On the other hand, a large spread sheet calculation simply can not be done using word processing software. The word processing software doesn't support the primitive functions, addition, subtraction, multiplication, etc that a spread sheet calculation requires. Some of the complex word processing functions can be emulated on a spread sheet but spell checking and grammar correction would be very cumbersome and difficult.

This is the sense that I am trying to convey, that people with a robust ToM can do good and robust communication that is nuanced, and well understood by others with a matching and robust ToM. Their shared ToM is analogous to the word processing software, and a well formatted document is analogous to human communication between individuals with a shared ToM. The ToR is analogous to the spread sheet software and the large spread sheet analogous to a highly technical ToR. A theory of cognition (ToC) would be the selection of the proper software type to do the required computations (ToM(English), ToM(French), ToM(ASL), ToR). There are multiple ToMs, each language is different to some extent, although there are other communication modes, body language, cultural signals, gestures. There is only one ToR, the one which accurately describes reality as it actually is. Individuals may have a ToR that is highly specialized and individualistic, physics or medicine for example. But all of the different ToRs all mesh into one (or should) because they all describe a single reality.

In this analogy I am trying to illustrate that a specialized piece of computation machinery may work very well for one task (word processing) and not at all for another (spread sheet calculation). If you tried to input a spread sheet into a word processor, you would get many error codes, many misspelled words; the word processing software would reject it as badly formed. A very well formed spread sheet cannot be read on a word processor. This is analogous the problem that some NTs have with understanding people with ASDs.

Normal background "housekeeping" features can impede communication. Many types of different word-processing software have automatic spell checking. If a word is spelled wrong, the software will change the spelling to match the spelling to one of the words in its dictionary. If the word is not misspelled, but is simply not in the dictionary, the software can't recognize it and will change it anyway. This is a type 1 error, a false positive. The software falsely identifies a character string and modifies it to match its default identity. This is an inherent property of specialized pattern recognition systems. There is a trade off of type 1 errors (false positive) for type 2 errors (non detection). If you don't have access to modify the "error correction function", it may be impossible to type certain strings because the error correction keeps changing them. In certain word processing software this can be extremely annoying and make writing outside the scope of the software impossible. If the software won't let you have certain character strings in your document, you can't write about them. If your ToM won't let you have certain ideas, you can't think about them. Appreciating that your ToM doesn't have the capacity to think certain thoughts is extremely difficult.

Being unable to conceptualize ideas is not uncommon. There are people who believe in the literal truth of ancient texts and are unable to conceive that they do not accurately describe reality, irrespective of what data can be collected today. These beliefs are from a ToM, shared with others of their community. Such beliefs did not arise from observations of reality, they were told to individuals by other individuals who believed them. Those false beliefs are derived by those false beliefs being communicated to the individual and so shaping their ToM. Such beliefs are often extremely resistant to change.

Learning can be looked at as modification of the brain's neural network so the neuroanatomy can support what ever new idea it is that is being learned. Usually this takes a long time and is quite difficult. Learning physics or mathematics is difficult because the normally developing neural patterning doesn't support that type of thinking the way it supports language. I will discuss this more later.

A mother's necessity makes her child an inventor.

Maternal stress --> fetal development along autism spectrum --> Asperger phenotype

The hypothesis of this paper is that low NO in utero causes development along the autism spectrum so as to program the brain in utero to one that supports a better ToR. Precisely the phenotype that is needed when mothers are stressed and so times are hard. What ever technology and cultural practices are being used, they are not working well enough and so new ones need to be developed.

Which individuals are most adept at tool use today? It is people with Asperger’s, people with ASDs. Many scientists and engineers have Asperger’s, and it is suggested that Einstein, Newton, and many brilliant scientists had Asperger’s. [22] Asperger even said “It seems that for success in science or art a dash of autism is essential.” [23] The stereotypical nerd is someone with facility at math, science and with characteristically poor social skills[24]. The mirror neuron system[25] (responsible for understanding the actions of other individuals) exhibits dysfunction proportional to ASD severity. [26]

The major barrier to revolutionary scientific innovation is conventional thinking and existing paradigms. [27] What Kuhn calls “normal science”. Ideas transmitted culturally are difficult to displace even when wrong. It is nearly 150 years since Darwin’s “Origin of Species”, with overwhelming data supporting and no datum inconsistent with evolution, yet in the USA, 40% of the population believes evolution is false. [28] Some on the Nobel Committee were unable to accept relativity as valid and so Einstein received the Nobel Prize for the photoelectric effect, not relativity. [29]

Cultural notions of what is appropriate affect abilities (i.e. what people think they or anyone can do). Women exposed to a hypothesis wrongly attributing mathematical ability to genes on the Y chromosome have impaired mathematics performance. [30] A degree of social isolation from disrupted mirror neurons may insulate ASD individuals from incorrect paradigms of science, technology and the peer pressure associated with cultural practices which must be abandoned to overcome hard times. No doubt 2.8 MYA everyone “knew” stones didn’t make good tools. The first stone tools were not developed after committees of peers reviewed proposals and selected the highest scoring for implementation; they were developed by the “Einsteins” of the time working alone. Acquisition of nut cracking skill by capuchin monkeys (Cebus apella) using stones as hammer and anvil takes about 2 years and requires considerable repetitive nonproductive effort while watching proficient individuals. [31] No doubt repetitive trial and error was needed to acquire de novo skill(s) to manufacture stone tools 2 MYA, and such individuals had to ignore criticism that they were bizarre for “uselessly” banging stones together.

These culture notions are transmitted through the robust NT ToM. To avoid being adversely influenced by potentially incorrect ToMs, ASDs require a weaker ToM, a ToM that perhaps allows some communication, but one that can easily be ignored, resulting in the ability to ignore the "Kool-Aid" which is a stronger version of groupthink. The delusional world views that some NTs have can become extremely compelling to them,, such that they are unable to perceive that it is delusional, particularly when a charismatic leader with a strong ToM (essentially the definition of a charismatic leader) imposes it on his/her followers. More on this later in the discussion of cargo cult science.

ASD individuals developing skills unrecognized as useful by NTs must possess a compulsion to acquire those skills despite peer pressure that such skills are useless. Many ASDs acquire skills that NTs think are useless, fascination with train spotting, bird watching, collecting, virtually every savant ability is acquired to a degree that NTs do not find useful (if they did, then NTs would acquire such skills to that degree and it would not be thought of as savant). Language and communication is the "savant" skill of NTs. NTs possess a skill at communication (with other NTs) that ASDs cannot hope to master. Just as ASDs sometimes have skills that NTs cannot hope to master. Just as elite athletes have skills that non-athletes cannot hope to master. A society with the ability to use the best skills of a highly variable and diverse group would be better able to cope with adversity than a society where all individuals had the same average abilities. Not every individual in the village needs to be proficient at making stone tools, provided there are enough proficient individuals and the tools their skills produce can be traded for other things.

Cognition: Non-algorithmic calculation

Cognition in human brains is done by neural networks, the fundamental details of which are mostly unknown. Some cognitive abilities (such as savant calendar) are known to be non-algorithmic because the errors are not always the same, and the time for performing the calculation is not asymmetric depending on calculation direction the way a computation performed using an algorithm would be. [32] It is likely that most if not all other types of human cognition are non-algorithmic.

I am using algorithm in the sense that an algorithm is what a Turing machine executes. An algorithm is a series of instructions that when acted upon manipulate data and perform a calculation. The computers that people are familiar with are algorithmic. Calculators use a calculating engine (the processor) to operate an algorithm (the software) to manipulate the data. In general the data does not modify the software or the processor while the computation is in process, and given the same data, the same processor running the same software will produce the same output each and every time the calculation is performed.

Neural networks are inherently non-algorithmic in the sense that there is no "algorithm" explicitly being implemented by the neural network. A neural network may be used to implement an algorithm. For example, humans and other animals have the ability to do approximate mathematical operations such as comparison. Two groups of objects can be compared and the one with the larger number can be selected even when the members of each group have not been counted. This selection can be made by individuals unable to count and even by animals. This selection is non-algorithmic. An individual able to count is also able to count the members of each group and then tell which group is larger by comparing the two values. The person, who can count, knows that the counting algorithm produces a more reliable comparison than the non-algorithmic visual comparison. The person who cannot count does not know how to implement the counting algorithm.

Human brains are not optimally configured to run algorithms. A processor that can run algorithms is in essence emulated in a human brain to run the algorithm under consideration, such as counting or multiplication. The form that the data is in may greatly limit what algorithms that data can be manipulated with. For example multiplication using Arabic numerals is easy. Multiplication using Roman numerals is exceedingly difficult. There is essentially no algorithm for multiplying Roman numerals, individuals use a look-up table. Learning algorithms takes considerable time and effort for many individuals.

Communication requires a Theory of Mind

Exactly how neural networks in the brain configure and reconfigure themselves to do the computations that certain cognitive tasks require is unknown. Presumably there is some type of feedback that modifies the network when sub-optimal results are achieved so as to configure the network to produce better results. How this occurs is unknown, but for language acquisition, some conclusions as to how this optimization works can be made which I discuss below. What I want to emphasize the compulsive aspects of language acquisition. People do not choose to acquire the language they acquire as children, their brains acquire it (or synthesize it de novo) for them.

All communication requires two parties, a sender and a receiver. The sender must have a mental concept, translate that mental concept into a communication medium, transmit that message to the receiver, who must receive and then translate that message back into a mental concept. In that sense, all communication is only the transmission of representations of internal mental states. For there to be communication, the mental concept must necessarily be mapable onto the neural structures of both individuals. If one party is not able to represent the mental concept in their brain, the concept cannot be communicated either from them or to them. In a sense, communication is the transmission of data that allows the receiver to identify and map that concept into a mental representation, in effect the receiver is doing pattern recognition on the data stream and generating a mental representation, in effect a pattern of thought either generated de novo, or a familiar pattern previously used.

In this sense, communication can only occur between individuals with a shared Theory of Mind. This is the sense that I am using ToM in this paper, the emulation of the cognition of another individual to achieve a mapping of the mental state of one individual with the mental state of another individual. The possible fidelity of that mapping determines the possible fidelity of that communication. If a mental state cannot be mapped onto another individual's ToM, then that mental state cannot be communicated to that individual.

Pattern recognition is a well recognized ability. All systems encoding pattern recognition are subject to different forms of error. There is the type 1 error, the false positive, the error in wrongly identifying a false instance as positive. There is also the type 2 error, the false negative, the error in missing the correct identification of a correct instance. In a general sense any pattern recognition system can be made more sensitive, that is with a reduced type 2 error, but then there is an increased type 1 error and there are more false positives.

A type 1 error is getting the attempted message wrong; a type 2 error is missing the attempted message. Since communication is a two-party interaction, the "fault" of miscommunication cannot be attributed to either party, the "fault" lies in their interaction.

Many human interactions engender other types of error. There is no generally accepted definition of what is a Type 3 error, but one definition is "the error committed by giving the right answer to the wrong problem". When times are hard, and the culturally transmitted traditional information isn't capable of solving the hard times, that is an example of the right answer to the wrong problem. The time of adolescence and early adulthood is often a time of rebellion against authority, against conventional wisdom, against cultural norms. Young people are testing the limits of their culturally acquired information; testing to see what works and what doesn't. This is somewhat speculative but this might be a mechanism to reduce the cultural transmission of obsolete or dysfunctional practices. In the absence of a written language, the only cultural practices that can be transmitted are those adopted by the next generation. If the older members of the tribe live long enough to transfer their wisdom to adults past their adolescent rebellion period, perhaps the wisdom is worth transferring. If not, then perhaps it isn't and the tribe should try new approaches until that happens.

Communication and language acquisition

Social animals communicate with each other. In humans the ability to develop language is innate and the brain structures to support language and language development must be coded for genetically. Language itself must be learned or is synthesized de novo during certain periods of brain development. This point is quite important. When humans are growing up in a culture, they adopt the language of the culture, provided that the language is "well formed". If the language the adults are using is not "well formed", the children synthesize a new language that is "well formed". That is, when the children of immigrant parents grow up, they do not adopt the pigeon language their parents are speaking, they either adopt the "well formed" dominant language, or synthesize a "well formed" Creole. The various sign languages did not become "well formed" until children grew up with signing as their first language, which they modified into a "well formed" language.

The acquisition of language in this way tells us several things; that the ability to acquire language is innate, that there is a more "primitive" cognitive structure underlying language (by that I mean that the structure of "thought" has a component that is simpler than the linguistic components humans communicate with). Without a simpler and more primitive cognitive structure, the Creole could not be analyzed as it is being formed to ensure the resulting Creole has a "well formed" grammar. However, the ability to form a Creole is lost at a certain age. The immigrant parents of the Creole synthesizing children continue to speak their pigeon language. This implies that the cognitive structure that analyzes language as it is being learned and forces it to be "well formed", i.e. to conform to standard human linguistic patterns is lost (to some extent) with age. It also implies a compulsion to learn the "standard" language and a compulsion to force others to comply with the "standard".

The development of a de novo language, such as a Creole, is a collective outcome produced by a population. It is not produced by a single individual. Another way of describing it is that the population developing the language acquires a shared neural mapping of the medium of the language (sounds, gestures, etc) to neural structures producing the mental states that are the ultimate outcome of communication (that is the ideas being communicated). In this context, there is no arbitrarily correct mapping. The mapping is correct so long as it is the mapping shared by the group. In the sense of the Galbraith quote at the start what ever the majority adopts as the linguistic mapping is the correct mapping. This is a very important point. What ever the majority adopts as correct is correct; everything else is wrong.

For a single majority linguistic mapping to arise spontaneously there must be very powerful mechanism(s) to eliminate deviation from the mapping acquired by the majority. The majority acquire a shared Theory of Mind with respect to linguistic mapping. In other words, the differences between the shared Theory of Mind and that of any individuals in the population are reduced. The deviation is not reduced by changes to the shared theory of mind; the deviation is reduced by individuals adopting the shared ToM as their own. This is an important point. There is no "shared" ToM. There are only individual ToMs which correspond to the shared ToM more or less. The shared TOM can only be shared to the extent that all individuals have the same components and the same structural relationships between those components. The shared ToM reflects the "lowest common denominator"; the ToM that overlaps with everyone else's ToM is all that can be shared. I think this relates to the importance of "peer pressure" in the age group capable of forming a Creole language. If peer pressure were not so compelling, a single coherent language would be difficult to achieve.

The rigidity of an inflexible ToM maintains stability of communication, of information transmitted culturally to the next generation. If your ToM doesn't support an idea, you cannot transmit it, receive it, understand it, or even think it. When times are easy, transmitting the cultural information that led to those easy times is important. It is important to do so with high fidelity because it worked. When times are hard, the culturally transmitted information isn't working, and so needs to be abandoned or modified. The fidelity of transmission must be reduced so what ever is wrong and/or isn't working can be eliminated.

The ToM of NTs that allows them to communicate so easily with each other limits what they can communicate to ideas that are within the shared ToM. This is an extremely important point, but it is a point that NTs have an extremely difficult time understanding because they can only think using ideas that are within their shared ToM. If an individual's ToM is insufficiently flexible to map an idea, that idea cannot be understood unless the ToM changes. But there is tremendous peer pressure to maintain the shared ToM of the group and to not change it.

This rigidity of the NT ToM is what causes ideas to persist even when those ideas are wrong and the rejection of correct ideas even when well supported by incontrovertible data. Many religious ideas have no supporting evidence and are in fact demonstrably wrong. For example the idea that the Earth is less than 10,000 years old and was created in 6 days as described in Genesis. Similarly the idea of evolution is rejected without a single piece of data inconsistent with it.

Most ToM ideas are transmitted from other individuals, not generated de novo.

Conflicting compulsions for ToM and ToR

A specific ToM is only useful for communication in the context of the group of individuals that share it. The mapping of a data stream (i.e. speech or gestures) into ideas and mental states is arbitrary and the only correct mapping is the one that everyone else in the group shares. There must be a tremendous compulsion to modify one's ToM to conform to that of the group. It is this compulsion that forces the emergence of a single language in a group.

In contrast, a ToR is only useful in so far as it actually corresponds to reality. To eventually develop a robust ToR, the individual must have a compulsion to modify his/her own ToR until it does correspond with reality, irrespective of the ToR of others in the group.

Thus developing and maintaining a good ToR is in conflict with developing a good ToM. A ToM needs to remain static for individuals to be able to communicate with each other. A ToR needs to be dynamic and change when ever it is found to be in error or to be dysfunctional.

I think this is the source of much of the resistance to new ideas in human culture but also in the scientific community. These concepts are laid out by Thomas Kuhn in his book, The Structure of Scientific Revolutions. Most scientists do what Kuhn calls "ordinary science", where they work within the paradigm of their scientific field. It is difficult to work outside the paradigms of a scientific field. Any contradiction of an existing paradigm is considered extraordinary and so requires extraordinary evidence. Some individuals are unable to reject paradigms even when they have been shown to be wrong. In these individuals, their rigid ToM has locked them into a perpetual state of error, and they don't have a sufficiently robust ToC to appreciate that their thinking is faulty and in error. It is mechanisms similar to the mechanisms that enforce a rigid ToM during language acquisition that compel adherence to the faulty ToM in later life, peer pressure, appeal to authority, tradition.

Communication and ASDs

Communication in humans encompasses a number of modalities including speech, sign language, body language, written language, music, artistic expression and perhaps pheromones. Most of these have components that are learned, improve with practice and degrade with disuse demonstrating the involvement of neural structures which retain plasticity (positive and negative) even in adulthood.

Autism is defined by behaviors, behaviors related to social interactions where autistic individuals have what are called characteristic deficits which can be reliably measured. However what constitutes a deficit is a matter of perspective. One example is a "deficit" in the ability to impute anthropomorphic motivation and emotion to inanimate objects as in the work of Frith. In this research, triangles were animated and made to move in three different ways, randomly, goal directed and moving interactively with implied intentions. The two sets of purposeful motions were designed to evoke anthropomorphic responses, e.g. chasing, fighting and coaxing, tricking. Individuals were scored on how closely they matched the scripts the animators of the triangles were trying to portray.

The ASD individuals scored lower than the NTs did, and this was described as a "mentalizing dysfunction". This was taken as a confirmation that people with ASDs have an impairment in attribution of mental states. However, whose "mental state" did the ASDs have an impairment in recognizing? The "mental state" of the triangles? Was this error a type 1 error (false positive), or type 2 error (false negative)? One might say the ASDs had a type 2 error, failure to recognize the "mental state" of the triangles, but one could (more correctly I think) say that the NTs had a type 1 error of falsely attributing a "mental state" to obviously inanimate triangles.

There is no intrinsically correct representation of the mental state of triangles. Triangles do not have mental states. The only way that a mental state can be attributed to triangles is via anthropomorphic projection of human-type intentions onto inanimate objects. In most circumstances this would be a Type 1 error; falsely observing anthropomorphic attributes in inanimate objects. It could also be thought of as a type 3 error, wrongly using a human based anthropomorphic model where it is inappropriate. This type of projection is not uncommon. Imputation of motivation and intentions to inanimate objects was at one time the basis for the religious belief that demons and spirits inhabit and animate virtually every object.

Inappropriate invocation of anthropomorphic feelings is a large part of the entertainment industry. Many cartoons are stylized after humans and many humans develop grossly and dangerously wrong ToR based on these erroneous ideas. In regions where bears are endemic, campers feeding bears is a serious problem. People assume that the anthropomorphic representations they have seen on TV are representative of how bears will react in real life. There have even been cases where a parent has applied peanut butter to a child's face so a bear cub would lick it off to obtain cute pictures.

This relates to the second quote, "If the only tool you have is a hammer, you tend to see every problem as a nail." If the only cognitive structures you have to think with are the cognitive structures of human emotions and communication, trying to figure out the properties of inanimate objects would consist of trying to ascribe human motivations and intentions to those inanimate objects and trying to figure out what they would do next in human terms.

Savant cognitive abilities

A striking feature of some people on the autism spectrum is that in some instances they have narrow and highly superior cognitive abilities. Human mental abilities have distributions in the population, with "normal" abilities being distributed "normally". Usually people with autism are somewhat lower on intelligence tests such as WISC, but with somewhat higher scores in block design. When intelligence tests without a communication component such as Raven's Progressive Matricies are used, some autistic individuals score much higher, in some cases as much as 70 percentile points higher (n=7). [33] That is 70 percentile points higher. Such a lack of congruence between tests is sufficient to show they are not measuring the same thing and we shouldn't use the same label to denote what the different tests are measuring even if there is good correlation among NTs. That correlation can only be spurious.

The distribution of intellectual abilities is "normalized", that is differences are measured and then scaled to fit on a distribution. That scale is arbitrary, and does not reflect any sort of absolute scale of difficulty.

As social animals, humans live in societies, larger communities of humans where there can be specialization and division of labor. It is this specialization and division of labor that has allowed humans to collectively master many technologies. Presumably different mental tasks are optimized by different neural structures. Dispersion in mental abilities requires dispersion in neural structures.

Savant abilities are not rare among people on the autism spectrum, and sometimes occur in individuals with profound disruptions in other cognitive abilities. This shows that to some extent, some cognitive abilities are independent of each other. Presumably superior performance in some cognitive tasks and inferior performance in others represents a trade-off of abilities along multiple spectra. The brain is limited in size, its computation capacity is limited, relative cognitive abilities of individuals will depend on the myriad details of the neurodevelopmental path that individual took.

Communication is "savant" ability of NTs

Many ASDs have savant abilities, which demonstrate that what ever part of the brain is providing those cognitive abilities has superior performance to the corresponding part of NT brains with lesser performance. The one area where NTs are universally better than ASDs is in communication. I suggest that communication is the savant ability of NTs, and that NTs have traded reduced abilities on ToR and ToC for enhanced ability in ToM.

The difficulty in relations between ASDs and NTs is that NTs don't appreciate that the ToM they are using for communication is a savant ability that ASDs don't share, and shouldn't be expected to be able to emulate. An ASD can't emulate the NT savant ability to communicate any more than an NT can emulate an ASD savant ability at mathematics. If you don't have the brain structures that can do the computations, you can't emulate the behavior. You might be able to fake how it sounds, but because the fundamental neural structures are not present, it is just an act and can't have the actual content.

Trying to think about Reality with a ToM is like doing Cargo Cult Science

Richard Feynman coined a term, Cargo Cult Science, to describe the practices of people who may be doing what they call experiments, but they are missing the fundamental intellectual honesty to be actually doing science. The term comes from the observation that tribes in the South Pacific would observe westerners arrive and set up landing strips which would bring aircraft laden with cargo, all sorts of goods that seemed to appear like magic. Along the lines of Arthur C. Clarke's observation that "any sufficiently advanced technology is indistinguishable from magic". They tried to understand the source of this cargo and how to get cargo for themselves using their understanding of reality. They generated a Cargo Cult, and proceeded to adopt rituals to try and cause cargo to appear.

This is really an excellent metaphor for trying to think about a subject with the wrong approach. Their thinking was that such good cargo had to come from the Ancestors, but the Ancestors would only bring such good cargo if they were communicated with in the right way, which the westerners knew how to do, so copy them and the cargo would appear. They built landing strips, control towers and populated them with radio control operators, but to no avail.

Explaining that their approach was wrong would fall on deaf ears. They don't have the background to understand where the cargo actually came from. They had anthropomorphized their observations and reduced them to the human terms they could understand using their ToM. They didn't come to their beliefs via facts and logic, facts and logic won't dissuade them from their beliefs.

Obviously there are multiple individuals involved, a leader and followers and the leader may achieve lots of things even if no cargo shows up. Presumably it is the charismatic persuasion of the leader using the leader's ToM that causes the followers to believe the leader. Simply by leading the effort to obtain cargo the leader achieves status over the others. Even when doing something completely useless and wrong, the society holds together if all of the members share the same ToM. Individuals not sharing the conceptualization of obtaining cargo by building airstrips would not fit in.

To people who have savant mathematical ability, those without it who are trying to emulate mathematical abilities can be seen as trying to do cargo cult mathematics. They can go through the motions, but don't have the ability to generate the content. Similarly, ASDs who try to communicate with NTs are doing cargo cult communication. They can go through the motions, but there is a lot of stuff that is being missed.

Neurological structures required to support an idea

The only ideas that an individual can think about are ideas that can be mapped into that individual's neural network. To learn a new idea, either the neural structure present is sufficiently flexible that the new idea can be mapped into it, or the neural structure must be modified until the new idea can be mapped onto it.

The process of learning a new idea must include as the first steps, the process of modifying the neural networks of the brain such that they can support the new idea being learned. Often the first step is "unlearning" ideas that are wrong. I think that this modification of the brain to support new ideas is why learning takes such a long time. New neural structures need to be made.

All mental representations require some level of neuronal "overhead" to be sustained. The details of how the brain does that are not understood. While the capacities of the brain are large, they are not infinite, and at some point trade-offs must be made.

Socially isolated individuals develop on an autism-like pathway.

All important physiological systems are under feedback control (that would be all physiological systems). Presumably an organ as important as the brain is also under feedback control, and this is reflected in the improved efficiency obtained through practice at certain mental tasks.

Presumably if there is a trade-off of ToM vs. ToR, then isolated individuals with no need for a ToM would develop a more robust ToR. This does appear to be the case in multiple organisms including humans, monkeys and rodents.

The classic work on socially isolated monkeys was done by Harlow in the 1960's, [34] and present animal welfare regulations would make such experiments problematic. Some monkeys were raised with no social contact at all, even with their mothers. Such monkeys were profoundly affected and exhibited rocking behaviors, self-injurious behaviors and profound disruption in abilities to interact with other monkeys. They were termed autistic by the experimenters.

Surprisingly, some of these socially isolated monkeys exhibited superior cognitive abilities. What is especially interesting is that these superior abilities were termed "deficits" by the experimenters. [35] Socially reared monkeys were conditioned with a tone and a startle stimulus. A redundant lamp was then paired with the tone. Socially isolated monkeys conditioned to the redundant light, the socially reared monkeys did not. The experimenters characterized the non-conditioning of the socialized monkeys to the redundant signal of the light as "blocking" the isolated monkeys then exhibited what was termed a "deficit" in blocking. Why the experimenters chose to use the term "deficit" to refer to a superior ability tells us something about the experimenters and their expectations about the socially deprived monkeys, not the monkeys.

Rhesus monkeys raised in social isolation have superior learning performance to those raised in social environments. [36]

Involvement of nitric oxide in social interactions and communication

The archetypal social interaction in mammals is the bonding of the mother to her infant. All mammals exhibit this behavior and have exhibited it for as long as mammals have suckled their young. The first social interaction all mammals have is with their mother. Even mammals thought of as primarily non-social do have this social interaction.

NO is involved in the development of the bonding and smell recognition that occurs in ewes within 2 hour of giving birth. Inhibition of nNOS blocks formation of that olfactory memory, and this blockage can be reversed by infusion of NO into the olfactory bulb. [37] Oxytocin is essential in the formation of normal social attachment in mice. [38] Reduction in oxytocin release following epidural anesthesia in heifers preceded a reduction in maternal bonding type behaviors[39]. Activation of the oxytocin receptor causes activation of nitric oxide synthase. [40] The connections that mediate maternal bonding can occur in the space of a few hours[41], limiting the distance over which axons must migrate to form these new connections.

Why NO is the signaling molecule that mediated the neural remodeling to cause maternal bonding makes evolutionary sense. Lactation is extremely energy intensive. If a mother does not have the metabolic resources to generate sufficient milk of sufficient nutritional quality to sustain her infant until it is weaned, she (and her infant) is better off not bonding to her infant and abandoning it. Spending metabolic resources on a reproductive attempt that will fail will reduce the success of potential future reproductive attempts. A failed reproductive attempt has no advantage either to the mother, or to the infant. An infant's best reproductive strategy in those circumstances is to do what ever increases the likelihood that the infant's mother will have a successful reproductive event later, so that the non-surviving infant may have a surviving sibling.

I discuss this at length in my blog on infanticide. Using NO as the positive signaling molecule to mediate maternal bonding directly couples maternal bonding to energy status. The low NO of metabolic stress directly reduces the degree and fidelity of maternal bonding. In extreme metabolic stress (the most important states for maternal bonding to be blocked) the maternal instinct turns from nurturing to infanticide. It needs to be appreciated that infanticide under conditions of extreme metabolic stress is as much a "maternal" instinct as is nurturing when times are better. I see infanticide as the brutally hard state that desperate metabolic stress induces in postpartum women.

Social isolation reduces NO generating neurons in the brain

When rodents are raised in a socially deprived setting, the numbers of NO producing neurons in some parts of their brains are reduced. [42] A reduction in basal NO in the brain due to development under socially isolated circumstances makes sense. Many social interactions are mediated via NO mediated pathways, including bonding and other pathways mediated through oxytocin. If the environment one is growing into is non-social, social neural pathways have little or no survival benefit. Better to develop the neural structures that will be useful.

Socially isolated individuals retain sufficient neural plasticity to partially recover

Social isolation at birth produced monkeys with profoundly disrupted social abilities. Experiments demonstrated that some of the disrupted social abilities could be restored. This involved the use of "therapist" monkeys, usually socially raised normal monkeys that were substantially younger than the isolated monkeys. [43] In females, a socially isolated female could recover somewhat and be an improved mother following pregnancy and raising an infant however many times the first born infants did not do very well but mothering did improve with subsequence births[44] demonstrating plasticity in neural networks mediating mothering behaviors during pregnancy and/or mothering activities. Since maternal bonding is the archetypal communication pathway for mammals, this suggests that other fundamental communication pathways have plasticity also.

With NO being involved in bonding, improved bonding and mothering interactions with subsequent births is consistent with increased neurogenic nitric oxide as a causal mechanism. If a non-social environment becomes social, reconfiguring neural structures to cope with social interactions would be advantageous.

Potential for treatment

I suggest an analogous treatment for ASD individuals may be to incorporate them into play groups with significantly younger NT children that are at similar developmental stages, but with sufficient adult supervision that nothing untoward can happen.

Doing this in the context of increasing NO levels via the techniques I am working on my have important therapeutic effects.

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